Date: 1686, 1689, 1697

"As soon as ever the Parts begin to be form'd by Nature, this Animal and active Principle begins to exert its Heat and Force, being lodged in the Heart as in the Centre of the Body, from whence, as the Vessels begin also to be form'd, it distributes it self towards the extreme Regions, communicat...

— Nourse, Timothy (c.1636–1699)

Date: 1711

"These active Liquors, which Admission find / Thro' the strait Paths, and leave the coarse behind, / Swift to the inmost Rooms their Passage beat, / And crowd around the Soul's Imperial Seat."

— Blackmore, Sir Richard (1654-1729)