Date: 1604

"How are the Soule and Body, Spirite and Flesh coupled together, what chaynes, what fetters imprison a spirituall Substance, an immortal Spirit in so base, stinking; and corruptible a carkasse?"

— Wright, Thomas (c. 1561-1623)

Date: 1641

"You may say that you occupy the citadel in your brain and there receive whatever messages are transmitted by the animal spirits which move through the nerves, and sense-perception thus occurs there, where you dwell, despite the fact that it is said to occur throughout the body."

— Gassendi, Pierre (1592-1655)